April 2023 – saenzyvaldes.com

Factors To Consider When Selecting A Good Cosmetic Dentist And Who Will Render Quality Services

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Porcelain Veneers

Submitted by: Efren Evans

Cosmetic dentistry is about improving one s smile, tooth and mouth appearance, and it can involve a good experience if adequate time is taken to consider all the factors that maximize the chances of getting professional services from a qualified cosmetic dentist. There are many factors that should be considered when selecting the best cosmetic dentist from available ones. First, the professionalism of the dentist maximizes the chances of getting professional services that will completely solve one s problem without the chances of recurring.

A professional cosmetic dentist is one that is highly knowledgeable and experienced on the various options regarding cosmetic dentistry. This knowledge is the pillar towards advising the patient about the most suitable option to take for a specific problem. It is evident that various patients will need specific solutions to their specific problems, which differ from others and the professional must be aware of these needs in order to advise correctly. This also requires him/her to have handled various problems related to dental health.

As far as options regarding dental cosmetics, a professional in this field must understand the existence of dental implants and when to apply them. A professional must be knowledgeable on issues relating to teeth bleaching with an intention of enhancing patient s smile. Other options include placement of dental veneers, tooth whitening and use of inlays/onlays.

[youtube]http://www.youtube.com/watch?v=8BBGInxEAlU[/youtube]

The expertise of a cosmetic dentist also determines how fast he/she will offer the solution. Some employ people who handle their clients in order to advise on initial problems that are not complicated. It is important to involve a professional in order to ensure that cosmetics on teeth do not have related side effects and will not lead to initial dental problems.

Some dental problems begin to manifest earlier before becoming complicated and it is therefore important for patients to involve professionals from the start. A professional will notice any complications as early and will advise the patient what to do. Complicated cases of dental diseases are difficult to handle and some minor problems result in loss of teeth. A professional will also use professional equipments in handling related problems if at all they manifest while doing the cosmetics. It is necessary to mention that a professional dentist must first make sure that there is no chance for development of problems related to dental parts.

It is advisable that anyone interested in seeking services of a dentist consider a cosmetic dentist who offers as many options as possible, just in case he/she needs other services in future. It maximizes the chances that the person handing other issues is aware of their previous diagnosis. In addition, someone offering as many options as possible is likely to gain an advantage of being charged cheaply with the knowledge that their problems were also handled previously. This is so when previous cosmetics result in more complications or need to be improved.

Although many people begin by selecting a cosmetic dentist who offers cheaper services in the market, it is advisable that the client begin with analyzing the quality of services offered. It is advisable that the client makes a list of these professionals known to offer high-quality services and select those who offer cheaper services from the list. Other factors must also be included to weigh the most suitable cosmetic dentist.

About the Author: Finding the best

Cosmetic dentist Los angeles

to take care of you, especially those near to you is easier online. Click here for

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Home Builders: How To Find Good Contractors

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Congratulations on your decision to build your own house. Theres nothing that can compete with the feeling that comes with knowing you are the first person to live in a house that was designed to your specifications. Now the important part: finding the right home builders. It isnt always the easiest task. There are those in the contracting business that exist solely to rip people off. There are others who are simply incompetent. And then there are those whose prices are sky high. To avoid all of these and find someone you can work with takes some research.Remember that you dont have to choose your home builders in a day. Take your time and plan to interview at least three to four different contractors. If you have access to an architect, ask them if they can recommend anyone. Do likewise with anyone you know who has experience in creating a house from scratch. The more input you can get, the better. People will be more than glad to turn you on to a great company and even more glad to steer you away from the bad apples. If you have plans already made up, be sure to let the home builders see them and have them express their thoughts. Try, if you can, to talk to the actual people who will be completing the job rather than the salesman for the company. You wont be working with the salesman when it comes to the construction of your house. Part of the process is finding someone who will not only listen to your ideas, but will give you good feed back and constructive criticism where you need it. You dont want to have to argue and fight on every point, but you also dont want someone who will just blindly say yes to everything, knowing full well that some of your ideas are impractical.Finally, get a price quote from each of your prospective home builders. They may not be able to hit it right between the eyes, but they should be able to give you a rough idea of the cost. If you have someone giving you a really high or a really low estimate, you know something is probably wrong. Find someone in the middle and judge them on the other important aspects of your search (including references, BBB reputation, and your personal rapport with them).

Indian Art}

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indian art

Salvage Cars

ArtsNyou.com Studios offers high quality modifications from creative paintings art in a variety of custom styles to a number of piercings like Art Prints, Posters, Canvas Prints, Photography, Oil Paintings, Glass painting and many others, we are proud to be customer friendly and innovative art store. ALL of our body art is performed by Professionally Experienced Artists and Piercers in a Clean, Sterile, Comfortable, Friendly, and Unique Environment! and have multiple years of Professional Experience in the paintings art Industry.

More Info : http://www.artsnyou.com/Incredible art every time : We work with passion to bring you the world’s largest art collection.

Whatever your interest, your dcor style, your inspiration we’re sure to have that piece you can’t live without.

Delight at every step : We believe art is dynamic, personal and connected to now, and the experience of buying and living with it should be too. From the moment you browse our site to the day your art is delivered, our team has one goal in mind: to delight you every step of the way.

Get inspired be inspired : You may know what art is right for you and your space… or you may need guidance to discover what you love. Either way, we’ve got all sorts of tools to help you explore, experiment and express yourself.

Hang With Us : Each and every day, we have more to offer you so keep in touch you never know what you’ll discover.

indian art

ArtsNyou is a leading name in buying and selling pictures, portraits and art prints online. Headquartered in Delhi, the company has an exemplary collection of over 1000 picture, portraits and art prints in its gamut. With affordability to masses, unbeatable quality and timely delivery as three pillars, ArtsNyou is progressing well to become the most preferred destination for buying and selling art work online.We at Artsnyou.com, your favorite Online Arts Gallery, work hard to spread the knowledge of Art far & wide. So that the art lovers have more information to decide and choose best art for them.

We facilitate the love for art. We empower our customers to choose the best in class Artworks with the best value for money. Please visit: www.artsnyou.comArtsNyou is a leading name in buying and selling pictures, portraits and art prints online. Headquartered in Delhi, the company has an exemplary collection of over 1000 picture, portraits and art prints in its gamut. With affordability to masses, unbeatable quality and timely delivery as three pillars, ArtsNyou is progressing well to become the most preferred destination for buying and selling art work online.ArtsNyou.com Studios offers high quality modifications from creative paintings art in a variety of custom styles to a number of piercings like Art Prints, Posters, Canvas Prints, Photography, Oil Paintings, Glass painting and many others, we are proud to be customer friendly and innovative art store. ALL of our body art is performed by Professionally Experienced Artists and Piercers in a Clean, Sterile, Comfortable, Friendly, and Unique Environment! and have multiple years of Professional Experience in the paintings art Industry.

More Info : http://www.artsnyou.com/Incredible art every time : We work with passion to bring you the world’s largest art collection.

Whatever your interest, your dcor style, your inspiration we’re sure to have that piece you can’t live without.

Hang With Us : Each and every day, we have more to offer you so keep in touch you never know what you’ll discover.

We facilitate the love for art. We empower our customers to choose the best in class Artworks with the best value for money. Please visit: www.artsnyou.com

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Removing Moss, Installing A Zinc Strip And Other Services Performed By Northern Virginia Roofing Or Another Roofing Company

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Medical Scrubs For Men

byAlma Abell

High humidity and moisture promote moss growth on asphalt shingles. If moss is covering several shingles on a commercial building, the following tips will assist with eliminating it and preventing future growth. Eliminating moss will reduce strain on roofing materials, which could lead to permanent damage or leaks.

Materials

[youtube]http://www.youtube.com/watch?v=SR4HtU03DUM[/youtube]

lawn and garden sprayer
oxygenated bleach
water
extension ladder
harness
long-handled scrub brush (stiff bristles)
chlorine bleach
plastic sheeting
water hose
measuring tape
flexible zinc strip
nails
nail gun

Removing Moss Plants And Stains

Oxygenated bleach and water need to be mixed together in a lawn and garden sprayer’s tank. A safety harness should be worn while standing on an extension ladder. After applying a cleaning solution to moss plants, a long-handled scrub brush that has stiff bristles can be used to loosen moss plants from asphalt. If surface stains remain on some shingles, chlorine bleach should be added to a lawn and garden sprayer’s tank to strengthen a cleaning solution.

Before applying a stronger solution to surface stains, plants and grass that are next to a commercial building should be covered with plastic sheeting so that they are not exposed to harsh chemicals. A cleaning solution should remain on shingles for several minutes to penetrate stains. Afterward, a scrub brush should be moved briskly over treated asphalt. A water hose can be used to rinse off clean shingles.

Installing A Zinc Strip

The top row of shingles should be measured before purchasing a zinc strip that is the same length. Nails should be spaced out evenly to secure the entire strip. The top of a zinc strip can be wedged underneath the bottom of each shingle that is secured to the top of a rooftop. Each time that it rains, zinc will be released from the strip and will run down a rooftop. Zinc will coat shingles and provide a barrier that will not be favorable for moss growth.

For assistance with removing moss or caring for asphalt shingles, individuals should contact Northern Virginia Roofing by visiting Osroofing.com or another roofing company’s website. Roofing specialists from Northern Virginia Roofing or another roofing company will inspect a rooftop before providing a quote and performing services.

Tips On How To Free Your Wheels From Being Stuck In Snow

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Quad Bikes For Sale

Submitted by: Criss White

Winter comes and along with it is the fun and revelry brought about by snow. Children playing, ice skating in the park and ice fishing are some things you can now enjoy. However, too much of anything can be bad and too much snow on the road is not good for you or your car for that matter. Being stuck in snow can be an annoyance. The difficulty of removing your car from being stuck in the freezing cold and dark weather is one of the key reasons people don t like snow. However, there are simple ways on how you can get you and your car safely back on the road. No matter how powerful your car is, safety should always come first and it is important to not rush and just take your time in getting out of the situation.

Survey your area and find out which route out you can use that has thinner snow patch. Do not rush as the wrong route can get you in deeper trouble. While the whole area may look knee-deep in snow, there are still some areas that you can go around that are slightly thinner.

Get your wheels as straight as possible before you even try to move out. Driving away from this problem would be a lot easier if your wheels are kept straight as wheels positioned sideways would be very difficult to maneuver. Straight wheels alone may not get you out, but it is an important step.

[youtube]http://www.youtube.com/watch?v=FReYV-hNVjs[/youtube]

Alternate between going forward and backward so that you create paths in the snow, which will make it a lot easier to get out of the snow. Do not struggle to go straight out as this will be more difficult. Instead, gather momentum as you go backwards and forward.

Control your wheel movement and do not rush. A sudden move in this slippery situation can make you lose traction and eventually, your control. Take your time because rushing to get out can make your car drift. Use the lowest gear shift setting.

If you are still stuck, then it may be helpful to get out of the car and manually remove some of the snow from around the tires. You can use your boots to kick some of the snow out of the way or if you have a small shovel, then you can use it to remove some of the snow and ice that is getting in the way.

If you feel you need tools to help you out, simple items like salt, sand and small stones or pieces of woods can help. Pour salt to help the ice melt while sand, small stones or pieces of stones can provide added traction as you find your way out.

Be thoroughly conscious and be prepared to apply brakes immediately so you can prevent even worse situations like spinning and skidding.

No one enjoys being stuck in the snow when driving. It all adds to inconvenience that is really not welcome, especially during the holiday season. But since Mother Nature has her own ways, we have to be armed with tools that can help us in such difficult situations.

About the Author: Criss White is a professional article writer for automotive, wedding, and various other topics. To view some

winter wedding favors

or to get other ideas for

wedding favors

visit Bridal and Wedding Favors. Note: This article may be reprinted in your ezine, blog, or website as long as the credits remain intact and hyperlinks remain active.

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Shed Plans 10×12 For Diy

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Rockhampton Industrial Shed Prices

By Verny L

For those of us who like to do things ourselves, shed plans 10×12 would come in handy for building that shed you want. If you are not sure where you could these kinds of plans, you should look online. There are all sorts of websites that offer these types of things, though you might want to check out everything that you get before you buy them. While most sites do try to make sure their plans are easy to understand and use; not all of them will. While some prices will vary a little bit, these plans should be reasonably priced as a general rule.

Some of the things that you are going to want to get with the shed plans 10×12 would be materials lists, easy to follow instructions, and diagrams. Most sites do make sure that all of these things can be used readily by the average person, but not all of them will make sure that they are easy. You should also look (if available) to see what kind of tooling their plans require. You are not going to want to go out and buy a bunch of expensive tools to do this. One of the reasons you are going to want to do it yourself is to save money, and you can’t do that if you are spending the money on tools you might never use again.

[youtube]http://www.youtube.com/watch?v=CZ2qiY-kS7Y[/youtube]

Now, I have already said that saving money is one of the reasons you might want shed plans 10×12, but there are others. You might want a certain style of shed that you cannot buy at the local stores. If you can, it will probably cost you a bit more because they have to order it. With plans you can choose which style you like. There are garden, barn, and even cottage style plans available to you. You are sure to find one that will suit your needs and taste from all the ones that are available on the internet. Also, remember that you can decide the final look as well with trim and paint.

Convenience in another reason for the use of shed plans 10×12. If you are ordering them online, chances are that you can download them right away. It also means that you can print out as many copies as you need (save the download to the computer). This is a really nice feature to make sure you always have what you need. Pages can always get lost or ripped, but you can print out another copy easily enough if you downloaded it.

These are just a few reasons why you might want to get shed plans 10×12. There are probably countless others out there. However, saving money, assuring quality, choosing styles, and convenience are still among the top ones. No matter which your reason is, you can get a lot of satisfaction out of doing the work yourself and saving hundreds of dollars while doing it. There is nothing better than having your cake and being able to eat it too.

About the Author: If you like building things yourself, or just like saving money,

shed plans 10×12

could be just what you need. For more information please

click here!

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Dimming Led Or Cfl, Difficult, Not Impossible!

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Electrical Engineering And Design Mudgee

Submitted by: Chris Horridge

Depending on which type of light you want to dim, choosing a dimmer switch can go from being a fairly simple task to a very complicated one. If you are dimming halogen or incandescent lighting loads then this is straightforward as most will function perfectly well. However, dimming Compact Fluorescent Lamp (CFL) or Light Emitting Diode (LED) can be complicated as both the dimmer switch and the light must be compatible. LED in particular is the hardest as there are many different types available, all containing different types of dimming technology. Downlights Direct works closely with both lighting and switch manufacturers to provide the most up-to-date advice and pre-sales support.

Leading Edge or Trailing Edge Dimmer?

Leading edge and trailing edge are two different types of dimmer technology. Leading edge is the most popular because it is cheaper. Leading edge contains a triac and a coil. Leading edge may buzz slightly when in operation and the minimum load is quite high. This is not a problem when dimming incandescent or halogen but can be when dimming CFL or LED. Trailing edge dimmers are now available that have a minimum adjustment dial, turning the dial down to its lowest setting allows less lamps to dimmed and a wider range of dimming i.e. 100% down to 10%.

Trailing edge technology uses solid state components like insulated gate bipolar transistors (IGBT). It has no triac or coil providing a silent, smoother dimming action. The other advantage of using trailing edge is that the minimum load is lower. When dimming some LED lights, such as the Halers EvoLED downlight the load is rated at 10W instead of 50W if using trailing edge. This allows for far more lights to be dimmed, potentially up to 30x lights on one switch.

When dimming CFL you must ensure that the lamp is dimmable. There are very few dimmable CFL lamps on the market mainly because LED has overtaken it. The most popular is the Megaman 11W GU10. This lamp needs to be turned up to full brightness on start up for a few minutes before it is dimmed or the life expectancy of the lamp will be reduced. Depending on the minimum and maximum wattage, the ECU range, GRID500 or MP500 are compatible. Although cheaper in price, dimming CFL is not worth the hassle; LED is better in every way:

[youtube]http://www.youtube.com/watch?v=ikEWly4wbZE[/youtube]

Like with CFL, you must ensure that the LED you choose is dimmable as most are not. LED technology has developed rapidly over the past few years however, dimmer switch manufactures have reacted slowly, if at all, to the change. There are many different types of dimmable LED bulbs and LED downlights available. Consequently, consumers are often challenged to understand which combinations of LEDs and dimmers are compatible.

LED bulbs are harder to dim than complete LED downlights. Downlights Direct recommends Philips branded dimmable LED bulbs for use with Richmond leading edge dimmers such as the ECU range, GRID500 or MP500 – this is a tried and tested solution that works successfully.

Complete LED downlights such as the Halers EvoLED will dim with both leading and trailing edge dimmers but not with all makes!

Having decided on which LED you want to install, selecting the correct LED dimmer switch should be based on the following:

1. Compatibility; ideally, the LED manufacturer will have a list of recommended dimmer switches. Selecting a random dimmer switch may work perfectly well however, a dimmer switch that is incompatible can cause flickering and in some cases, permanent damage to the LED.

2. Quantity of LEDs; dimming results can vary depending on how many LED lights are in the circuit. LED loads are not rated the same as halogen, for example 10x5W LEDs is not the same as1x50W halogen. De-rating factors may need to be considered and vary from brand to brand. Selecting a compatible dimmer for the wrong quantity of LED lights could cause flickering and reduce the range of dimming, i.e. the lights won t dim down to 10%.

3. Aesthetics; if you like the look of your current dimmer switch but it is not compatible and causes your LEDs to flicker; modules such as the MP500 can be easily swapped. Keep the look, upgrade the technology.

To summarise, Downlights Direct has spent a lot of time and effort researching this task and can confidently advise on the best LED and dimmer switch combination for your lighting installation.

Advanced Dimming

Our range of dimmer switches doesn t end with compatibility; we offer some of the most advanced types of dimming systems available anywhere in the world. From remote control operated dimmer switches to wirelessly controlled lighting solutions. We have components available that can allow you to dim or control the lights in your living from anywhere in the world, using a PC, iPad or iPhone.

Visit Downlights Direct.co.uk for a total dimming solution.

About the Author: Chris Horridge is the Internet Marketing Specialist for

Expert-electrical.co.uk

If you wish to find out more about downlights or low energy lighting as well as information about Downlights Direct, go to

downlightsdirect.co.uk

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Pond Liners Buyer Beware

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Submitted by: Doug Hoover

Do you waste your money on lottery tickets? Feed your hard earned money to the one-armed bandits in the casinos? Drive without a seat belt? Then a pond liner is for you. You obviously like taking chances and are not too concerned about the outcome. Well, when someone spends thousands of dollars on a liner pond, they are playing the odds. Will their liner pond leak or not. From my 26 years experience in the pond business, I can assure you that the odds are not in your favor. This is an article the liner pond dudes do not want you to read. If you were not giving my industry such a bad name, there would be no need for this writing.

The liner pond gurus such as the “Liner messiah” with his own magazine and catalog, recruits unsuspecting followers with a “Build a Liner Pond Day”, and shows how easy it is to get something for next to nothing. Here is what these liner pond guys do:

o Lay out the pond with a garden hose

o Remove the sod and dig the hole

o Drop in our guaranteed line

o Fill with wate

o Drop in our pump

o Run our pipe

o Throw a piece of our liner on the pile of discarded dirt

o Stick in our filte

o Cover pile of dirt with loose rock

o Turn on our pump

o Throw in your fish

[youtube]http://www.youtube.com/watch?v=65C9OLvmjpI[/youtube]

o Collect your money and split.

Does this sound a bit harsh on the pond liner industry? Well, here is “the rest of the story. “I am going to add a few more items that the liner pond guys omitted:

o Ground squirrels

o Gophers

o Mice

o Rats

o Chipmunks

o Moose

o Sharp rocks

o Heavy rocks

o Falling rocks

o Sharp objects

o Tree roots

o Plant & weed roots

o Leaky drain seal

o Leaky skimmer seal

o Kids with sharp or pointed objects

Did the liner pond guy offer you a discount if any of the above occurred in your pond? Here is what you would have had to do if any of them happened in your newly-built liner pond (and I know the Liner Guy did not give you this list):

o Take out the fish

o Turn off the pump

o Take out the loose rock (hope you did not use too many)

o Pump out the pond

o Take out the pump

o Take out the line

o Spread out the liner on the lawn

o Clean off the dirt and algae

o Inspect every square inch of the liner for holes.

(Sure, there are short cuts, but if you assume you have fixed the problem after patching a hole, put everything back and then discover there was more than one hole, you might be a tad irritated. Remember this rule of thumb: one pinhole and you can lose five gallons of water every 24 hours!)

o Patch the hole or holes

o Repeat the whole process over again, only in reverse.

Hey, sound familiar? It should, with the exception of laying out the garden hose and digging a hole, you have just built another water feature!

If it had been done the professional way to begin with, all this time to tear it apart and put it back together could have been used to design and build another permanent project with steel and concrete.

Can you imagine if this scenario was referring to a project involving large boulders that were set in place with heavy equipment such as an end loader or crane? Not to mention lawn sprinklers, flower gardens, trees and shrubs that were growing there, and sidewalks and hardscapes installed! It can cost 30% more to tear out a liner pond and replace it with a professional one made with rebar and concrete. Where as if they had built a professional waterfall and pond in the first place it would have only cost about 20% more. Does the term penny wise and pound foolish mean anything to you?

Look before you leap and research before you weep. Happy koi, peace and joy.

About the Author: Douglas C. Hoover, engineer, author, designer & builder of over 2,000 waterfall and ponds in CA (30 years). Author of Waterfall and Pond Construction Manual, was $49.00, but for a limited time only $14.95 as a downloadable e-book. for more free information and photos go to

aquafill.com

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Why People Love And Collect Antique Cars

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Submitted by: Donk

Antique cars and classic cars collecting, restoring, and showing have become the number one pass time for many classic car enthusiasts. Whether you’re new to antique cars as a hobby, or a seasoned collector, the internet has information on classic cars, car parts, accessories, car shows and antique car sales, and more.

The first antique automobile was made in 1672 by a Chinese monk, and was steam powered. Then, around 1769, The Cugnot Steam Trolley was capable of transporting humans was produced. Other steam engine cars followed. By today s standards, the steam car would be considered a green alternative to modern gas guzzlers. New hybrid cars still don’t operate on nothing but steam power like the steam trolley did over two hundred years ago.

It wasn’t until 1806 that the first car with an internal combustible engine appeared. The internal combustible engine cars began to hook us all on vehicles that were powered with the use of gas and oil. In 1885, a more modern version of the internal combustible engine car was introduced. Even electric cars were designed very early in the twentieth century, but faded out in favor of gas powered vehicles. The Ford Museum, in Detroit, MI. still has a running, working model of Ford’s first electric motor on display. Antique Ford cars are highly collectible and well known in classic car circles.

[youtube]http://www.youtube.com/watch?v=vFiTk0FeBFk[/youtube]

There are several eras of collectible automobile history. Each era has a specific term to define the particular types of classic cars made during those time frames. Knowing certain antique car terms can help you to decide which antique car era you want to focus on as an antique car collector or restorer.

Classic cars from the 1890’s and earlier are termed “Veteran Era” antique autos. From around the 1900’s to 19190, those classic cars are generally referred to as the “Brass”, or “Edwardian” era collector cars. A very popular area for antique car collectors is the “Vintage” 1920’s era classics. Through the 1930’s to the 1950’s, there are “Pre-war” era classic cars. 1950’s through 1970’s are termed: “Post-war” classic or antique cars.

Cars that are twenty years old or older are generally referred to as “antique” cars. Another classic and collector car term you will hear is the term: “muscle cars”; which generally refer to sports cars made between the 1960’s to 1980’s. Whatever your classic antique car interest may be, the internet gives all the information, history, and antique car sales.

Antique Car collecting and restoration is a hobby practiced by people all over the world. Even American celebrities fall in love with them. Jay Leno, in addition to hosting the Tonight Show, is known for his huge collection of antique cars and motorcycles going all the way back to the early 20th century. Past stars known for their love of cars are Larry Hagman and Steve McQueen.

One of the reasons people love antique cars is that, for them, it brings back childhood or teenage memories. Maybe they had their first date in that car, or that is the car the family when on annual picnics, or maybe it was the car to have when they were young but they couldn’t afford it. The nostalgia market is worth billions of dollars and those longing for the antique autos of their youth account for only a small piece of it.

About the Author: I hope you found this article useful. Get the best

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Human cells grow blood vessels in mice

Sunday, July 20, 2008

Researchers in the United States reported Saturday that cells from human bone marrow, blood and umbilical cords successfully grew into blood vessels after being placed in mice. The group at Harvard Medical School and Children’s Hospital Boston stated that the human cells, referred to as “progenitor cells”, connected to the circulatory system of the mice. The team, lead by Harvard associate professor of medicine Joyce Bischoff, reported their findings in the journal Circulation Research, published by the American Heart Association.

Red blood cells (erythrocytes) Image: Drs. Noguchi, Rodgers, and Schechter of NIDDK (National Institutes of Health).

Juan M. Melero-Martin, a co-author of the paper in Circulation Research, said that one of the project’s goals is to be able to replace some types of heart surgery with an injection of cells grown in a lab that could develop into functioning blood vessels.

“For clinical use, the way we envision it, if a patient has need to vascularize ischemic tissue, we can get cells from the patient ahead of time, grow them and inject them back into the patient,” said Melero-Martin.

Ischemic tissue refers to tissue that has been damaged due to a lack of blood flow from blocked arteries or other causes. Researchers hope to be able to speed up the process of repairing damaged tissue and vessels in the heart to a period of one or two days. The procedure could potentially be used to treat organs damaged by heart attacks, or other ailments which impede circulation.

Due to their controversial nature the research team did not use stem cells in their study, but rather relied on progenitor cells taken from bone marrow or blood. “Our next goal down the line is to use them in humans. We need to do a lot more animal studies to test how these cells behave in different tissues,” said Joyce Bischoff.

Dr. Nick Rhodes of the UK Centre for Tissue Engineering at the University of Liverpool described the results of the study as “interesting and promising”, and commented: “Although this approach is not yet suitable for clinical use, it is interesting that they have demonstrated you have all the elements you need to create a functional network of capillaries from a small amount of blood.”

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